The Medical Letter on Drugs and Therapeutics
Pimavanserin (Nuplazid) for Parkinson's Disease Psychosis
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.

The FDA has approved the atypical antipsychotic pimavanserin (Nuplazid – Acadia) for treatment of hallucinations and delusions associated with Parkinson's disease. It is the first drug to be approved in the US for this indication.

PARKINSON'S DISEASE PSYCHOSIS — Hallucinations and delusions occur in up to 60% of patients with Parkinson's disease.1 Low doses of clozapine (Clozaril, and others) have been effective for treatment of these symptoms, but even in low doses clozapine can cause agranulocytosis, somnolence, and other significant toxicity.2,3 Low-dose quetiapine has been used off-label to treat Parkinson's disease psychosis, but it has not been effective in controlled trials.4,5 Both clozapine and quetiapine block dopamine receptors and could exacerbate the motor symptoms ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: Pimavanserin (Nuplazid) for Parkinson's Disease Psychosis
Article code: 1496b
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian