The Medical Letter on Drugs and Therapeutics
Ameluz for Actinic Keratoses
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The FDA has approved a 10% nanoemulsion gel formulation of the porphyrin-based photosensitizer aminolevulinic acid hydrochloride (ALA; Ameluz – Biofrontera) for use in combination with a narrowband red light photodynamic therapy (PDT) lamp (BF-RhodoLED) for treatment of actinic keratoses (AKs) of mild to moderate severity on the face and scalp. A 20% ALA solution (Levulan Kerastick) approved for use in combination with blue light PDT (BLU-U) has been available in the US since 2002.1

ACTINIC KERATOSES — Common in older, lighter-skinned persons with a long history of sun exposure, AKs are gritty, scaly, red- or flesh-colored papules or plaques caused by UV radiation-induced abnormal keratinocyte proliferation. AKs commonly regress and reappear, and most only cause cosmetic harm, but they are considered precancerous with a risk of progression ... more      

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Title: Ameluz for Actinic Keratoses
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