The Medical Letter on Drugs and Therapeutics
Sublingual Nitroglycerin Powder (GoNitro)
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The FDA has approved a sublingual powder formulation of nitroglycerin (GoNitro – Espero) for prevention or acute relief of an attack of angina pectoris. It is the first powder formulation of nitroglycerin to become available in the US. Most patients with angina use sublingual nitroglycerin tablets (Nitrostat, and generics). Translingual spray formulations of nitroglycerin (NitroMist, Nitrolingual Pumpspray, and generics) are also available.1

CLINICAL STUDIES — In an unpublished, randomized, double-blind, crossover trial in 51 patients with exertional angina pectoris (summarized in the package insert), doses of nitroglycerin powder ranging from 200-1600 mcg produced significant, dose-related increases in exercise tolerance, time to onset of angina, and time to ST-segment depression, compared to placebo. No clinical studies comparing nitroglycerin ... more      

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Title: Sublingual Nitroglycerin Powder (GoNitro)
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