The Medical Letter on Drugs and Therapeutics
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1521
Valbenazine (Ingrezza) for Tardive Dyskinesia
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The FDA has approved valbenazine (Ingrezza – Neurocrine Biosciences), a vesicular monoamine transporter 2 (VMAT2) inhibitor, for treatment of tardive dyskinesia in adults.1 It is the first drug to be approved in the US for this indication; two other VMAT2 inhibitors, tetrabenazine (Xenazine, and generics) and deutetrabenazine (Austedo), were approved earlier for treatment of chorea associated with Huntington's disease.

TARDIVE DYSKINESIA — Tardive dyskinesia is a neurological disorder characterized by stereotypical, repetitive, involuntary movements of the mouth, tongue, face, trunk, and extremities. It can occur with prolonged use of antidopaminergic drugs, especially first-generation antipsychotics and metoclopramide (Reglan, and others).

There is no standard treatment for tardive dyskinesia. If possible, the precipitating drug should ... more      

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Title: Valbenazine (Ingrezza) for Tardive Dyskinesia
Article code: 1521b
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