The FDA has approved the selective alpha_1A-adrenergic receptor agonist oxymetazoline as a 1% cream (Rhofade – Allergan) for topical treatment of persistent facial erythema of rosacea in adults. Brimonidine, a selective alpha₂-adrenergic receptor agonist, was approved in 2013 as a 0.33% gel (Mirvaso) for the same indication.1 Like Mirvaso, Rhofade is not indicated for treatment of inflammatory lesions of rosacea. Oxymetazoline has been available over the counter for many years as a nasal decongestant spray (Afrin, and others).

TREATMENT OF ROSACEA — Rosacea is a common, chronic inflammatory facial condition of unknown cause characterized by erythema, telangiectasia, and/or acneiform lesions (papules and pustules), usually on the central part of the face. Avoidance of exposure to extremes of temperature, hot baths ... more      

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