The Medical Letter on Drugs and Therapeutics
FROM
ISSUE
1523
Acetylcysteine (Cetylev) for Acetaminophen Overdose
Subscribers: Log in to read full article.  Not a subscriber?  Subscribe or purchase article.

The FDA has approved an effervescent tablet formulation of acetylcysteine (Cetylev – Arbor) to prevent or lessen hepatic injury after acetaminophen overdose. Acetylcysteine has been available for years in an IV solution (Acetadote, and generics) and an oral solution for the same indication; use of the oral solution has been limited by its unpleasant odor and taste.

MECHANISM OF ACTION — Acetylcysteine prevents hepatotoxicity by replenishing glutathione and detoxifying N-acetyl-benzoquin oneimine (NAPQI), the highly reactive metabolite of acetaminophen.

ACETAMINOPHEN OVERDOSE — Acetaminophen (paracetamol; Tylenol, and others) is one of the most common drugs taken in overdose. It is available in single-drug immediate- and extended-release formulations, and as a component of many cough, cold, allergy, and analgesic products. Acetaminophen overdose can cause serious ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscribe
Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: Acetylcysteine (Cetylev) for Acetaminophen Overdose
Article code: 1523c
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian