The Medical Letter on Drugs and Therapeutics
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Insulin Degludec/Liraglutide (Xultophy 100/3.6) for Type 2 Diabetes

The FDA has approved Xultophy 100/3.6 (Novo Nordisk), a fixed-ratio combination of insulin degludec and the GLP-1 (glucagon-like peptide-1) receptor agonist liraglutide, for once-daily treatment of adults with type 2 diabetes inadequately controlled on basal insulin (<50 units daily) or liraglutide (≤1.8 mg daily).

Soliqua 100/33, a long-acting insulin/GLP-1 receptor agonist combination that contains insulin glargine (Lantus, and others) and lixisenatide (Adlyxin), has also recently become available in the US.1 

GLP-1 RECEPTOR AGONISTS — GLP-1 receptor agonists lower glucose levels by potentiating glucose-dependent insulin secretion, suppressing postprandial glucagon secretion, slowing gastric emptying, and promoting satiety. They lower glycated hemoglobin (A1C) by about 1-1.5%, have been associated with weight loss of 1.5-2.8 kg, ... more      

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