The Medical Letter on Drugs and Therapeutics
Tisagenlecleucel (Kymriah) for ALL
The full article is available to subscribers Subscriber Login   

The FDA has approved tisagenlecleucel (Kymriah — Novartis), an individualized, genetically-modified cellular product, for treatment of relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL) in patients ≤25 years old. The patient's own T cells are genetically modified to express chimeric antigen receptors (CAR) and then reinfused. Kymriah is the first CAR T-cell immunotherapy to become available in the US. A CAR T-cell product for B-cell non-Hodgkin's lymphoma is expected to be approved soon.

TREATMENT OF ALL — ALL is the most common cancer in children. About 80% of children respond to first-line chemotherapy, but if leukemia recurs, it is less responsive to subsequent interventions. For non-responders or patients who respond initially and then relapse, allogeneic hematopoietic cell transplantation is often required to achieve remission or cure. ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Immediate Online access to current issue and archives from 1988 to the present
  • Mobile access to our mobile site and free apps for iOS, Android and Kindle
  • FREE online per issue CME/CE
Free trial offer
3 Free Issues of The Medical Letter on Drugs and Therapeutics mailed to your home or office PLUS online access.
Try a Free Trial Subscription
Purchase this article:
Title: Tisagenlecleucel (Kymriah) for ALL
Article code: 1532b
 Electronic, downloadable article - $25