The Medical Letter on Drugs and Therapeutics
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1533
Abemaciclib (Verzenio) - A Third CDK 4/6 Inhibitor for Breast Cancer
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The FDA has approved abemaciclib (Verzenio – Lilly), an oral cyclin-dependent kinase (CDK) 4/6 inhibitor, for treatment of hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. Abemaciclib is the third CDK 4/6 inhibitor to be approved in the US for this indication.

MECHANISM OF ACTION — CDKs 4 and 6 regulate the G1/S phase transition within the cell cycle; they are often overexpressed in HR-positive breast cancer, leading to cell cycle progression and cellular proliferation. Inhibition of CDK 4/6 results in cell cycle arrest, senescence, and apoptosis.

CLINICAL STUDIES — In a single-arm trial (MONARCH 1), 132 women with HR-positive, HER2-negative metastatic breast cancer that had progressed on or after endocrine therapy and had been treated with one or two chemotherapy regimens for metastatic ... more      

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Title: Abemaciclib (Verzenio) - A Third CDK 4/6 Inhibitor for Breast Cancer
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