The Medical Letter on Drugs and Therapeutics
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1537
Triptorelin (Triptodur) for Central Precocious Puberty
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The FDA has approved an extended-release intramuscular suspension formulation of the gonadotropin-releasing hormone (GnRH) agonist triptorelin (Triptodur – Arbor/Debiopharm) for twice-yearly treatment of central precocious puberty (CPP) in children ≥2 years old. Triptorelin has been available in the US for years as Trelstar for palliative treatment of advanced prostate cancer. Before the approval of Triptodur, Trelstar was used off-label for treatment of CPP.

THE DISORDER – Central precocious puberty (also known as gonadotropin-dependent precocious puberty) is caused by early maturation of the hypothalamic-pituitary-gonadal (HPG) axis and defined by early-onset sexual development occurring before the age of 8 years in girls and 9 years in boys. It is more common in girls than in boys, affecting about 1 in 5,000-10,000 girls. Characteristics of CPP include early breast ... more      

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Title: Triptorelin (Triptodur) for Central Precocious Puberty
Article code: 1537d
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