The Medical Letter on Drugs and Therapeutics
Issue 1543
Delafloxacin (Baxdela) - A New Fluoroquinolone Antibiotic; Secnidazole (Solosec) for Bacterial Vaginosis; Voretigene Neparvovec-rzyl (Luxturna) for Inherited Retinal Dystrophy; Dapagliflozin/Saxagliptin (Qtern) for Type 2 Diabetes; In Brief: Two New Drugs for AML (online only); Comparison Table: Some Systemic Fluoroquinolones (online only); Comparison Table: Some Antibiotics for MRSA Skin and Skin Structure Infections (online only)
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Delafloxacin (Baxdela) - A New Fluoroquinolone Antibiotic

The FDA has approved delafloxacin (Baxdela – Melinta), an anionic fluoroquinolone antibiotic, for oral and parenteral treatment of adults with acute bacterial skin and skin structure infections (ABSSSIs), including those caused by methicillin-resistant Staphylococcus aureus (MRSA). It is the first fluoroquinolone to be approved for treatment of MRSA.

ABSSSIs — The FDA's definition of an ABSSSI includes cellulitis/erysipelas, major cutaneous abscess, wound infection, or burn infection, with a minimum lesion size of 75 cm2 and symptoms of systemic infection. Patients with chronic infections such as diabetic foot and decubitus ulcer infections, human and animal bites, and necrotizing fasciitis are excluded from ABSSSI trials.1

STANDARD TREATMENT — In many parts of the US, purulent skin and soft-tissue infections are now ... more      

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