The Medical Letter on Drugs and Therapeutics
Secnidazole (Solosec) for Bacterial Vaginosis
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The FDA has approved secnidazole oral granules (Solosec – Symbiomix/Lupin) for single-dose treatment of bacterial vaginosis (BV) in adult women.

THE NEW DRUG — Secnidazole is a nitroimidazole antimicrobial with a longer half-life than metronidazole (17 vs 8 hours). It has been available for decades in many other countries for treatment of BV, trichomoniasis, and other infections.1


BACTERIAL VAGINOSIS — In patients with BV, hydrogen peroxide-producing lactobacilli in vaginal flora are replaced by an overgrowth of other bacteria, including anaerobes such as Gardnerella vaginalis, which leads to production of malodorous amines and an increase in vaginal secretions. Patients with BV are often asymptomatic, but vaginal discharge and/or a fishy vaginal odor can occur. In the US, the prevalence of BV is 29% among all women ... more      

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Title: Secnidazole (Solosec) for Bacterial Vaginosis
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