The Medical Letter on Drugs and Therapeutics
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Deutetrabenazine (Austedo) for Huntington's Chorea and Tardive Dyskinesia

The FDA has approved deutetrabenazine (Austedo – Teva), a vesicular monoamine transporter 2 (VMAT2) inhibitor, for treatment of chorea associated with Huntington's disease and, more recently, for treatment of tardive dyskinesia in adults. It is the second VMAT2 inhibitor to be approved for each of these indications; tetrabenazine (Xenazine, and generics) was approved earlier for Huntington's chorea1 and valbenazine (Ingrezza) was recently approved for treatment of adults with tardive dyskinesia.2

HUNTINGTON'S DISEASE — Huntington's disease is an autosomal dominant, progressive neurodegenerative disorder caused by mutations in the huntingtin (HTT) gene that encodes the huntingtin protein. No available treatment slows progression of the disease, but symptomatic treatment of depression, anxiety, cognitive impairment, ... more      

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