The Medical Letter on Drugs and Therapeutics
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1545
Ibalizumab-uiyk (Trogarzo) for Multidrug-Resistant HIV
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The FDA has approved ibalizumab-uiyk (Trogarzo – Theratechnologies/TaiMed), a CD4-directed monoclonal antibody, for IV treatment of multidrug-resistant HIV-1 (MDR-HIV) infection in heavily antiretroviral-experienced adults with treatment failure on their current regimen. Ibalizumab-uiyk is the first biologic drug to be approved by the FDA for treatment of HIV-1 infection.

MDR-HIV INFECTION — When full virologic suppression (viral load <50 copies/mL) cannot be achieved in patients with HIV-1 infection because of resistance to all available therapeutic options, goals of treatment should include preventing clinical progression and mitigating further development of resistance that might compromise future treatment options. Partial virologic suppression has been associated with clinical benefit1,2; even when viremia occurs and the CD4+ count does not ... more      

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Title: Ibalizumab-uiyk (Trogarzo) for Multidrug-Resistant HIV
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