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The Medical Letter on Drugs and Therapeutics
Copanlisib (Aliqopa) for Relapsed Follicular Lymphoma (online only)
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The FDA has granted accelerated approval to copanlisib (Aliqopa – Bayer), an intravenously administered phosphatidylinositol 3-kinase (PI3K) inhibitor, for treatment of adults with relapsed follicular lymphoma who have received at least two prior systemic therapies. Follicular lymphoma is a common subtype of non-Hodgkin's lymphoma. Copanlisib is the second PI3K inhibitor to be approved for this indication; idelalisib (Zydelig), which is administered orally twice daily, was the first.1

STANDARD TREATMENT — Treatment options for relapsed follicular lymphoma include immunotherapy with an anti-CD20 antibody such as rituximab (Rituxan) plus chemotherapy with an alkylating agent such as bendamustine (Treanda), radioimmunotherapy, and autologous stem cell transplantation. Treatment options are limited for patients whose disease does not respond to ... more      

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Title: Copanlisib (Aliqopa) for Relapsed Follicular Lymphoma (online only)
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