The Medical Letter on Drugs and Therapeutics
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ISSUE 1553
ISSUE 1553
August 13, 2018
Ciprofloxacin Otic Suspension (Otiprio) for Acute Otitis Externa
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August 13, 2018 (Issue: 1553)
The FDA has approved a 6% otic suspension formulation of the fluoroquinolone antibiotic ciprofloxacin (Otiprio – Otonomy) for single-dose treatment of acute otitis externa (swimmer's ear) caused by Pseudomonas aeruginosa or Staphylococcus aureus in patients ≥6 months old. Otiprio was approved earlier for prophylaxis in children with bilateral otitis media with effusion who are undergoing tympanostomy tube placement.1
ACUTE OTITIS EXTERNA – S. aureus or P. aeruginosa infection is the most common cause of acute otitis externa.2 In a meta-analysis of 19 trials, topical antibiotics, antiseptics, glucocorticoids, and acidifying agents were equally effective.3 Topical antibiotic therapy is the treatment of choice. Cure rates with topical
... more- Ciprofloxacin (Otiprio) for tympanostomy tube insertion. Med Lett Drugs Ther 2016; 58:69.
- RM Rosenfeld et al. Clinical practice guideline: acute otitis externa executive summary. Otolaryngol Head Neck Surg 2014; 150:161.
- V Kaushik et al. Interventions for acute otitis externa. Cochrane Database Syst Rev 2010; 1:CD004740.
- RM Rosenfeld et al. Systematic review of topical antimicrobial therapy for acute otitis externa. Otolaryngol Head Neck Surg 2006; 134(4 Suppl):S24.
- DD Walker et al. In vitro susceptibility of ciprofloxacin-resistant methicillin-resistant Staphylococcus aureus to ototopical therapy. Otolaryngol Head Neck Surg 2018; 158:923.
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