The Medical Letter on Drugs and Therapeutics
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1561
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Baloxavir Marboxil (Xofluza) for Treatment of Influenza

The FDA has approved baloxavir marboxil (Xofluza – Shionogi/Genentech), the first polymerase acidic (PA) endonuclease inhibitor, for single-dose, oral treatment of acute uncomplicated influenza in patients ≥12 years old. Baloxavir is the first drug with a new mechanism of action to be approved for treatment of influenza in almost 20 years.

STANDARD TREATMENT — Neuraminidase inhibitors, which are active against both influenza A and B viruses, have been the drugs of choice for treatment and prophylaxis of influenza for many years. They are most effective when started within 48 hours after symptom onset.1 Oral oseltamivir (Tamiflu, and generics) and inhaled zanamivir (Relenza) are FDA-approved for treatment and prophylaxis of influenza. IV peramivir (Rapivab) is FDA-approved only for treatment of influenza. Neuraminidase ... more      

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