The Medical Letter on Drugs and Therapeutics
Angiotensin II (Giapreza) for Septic Shock
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The FDA has approved Giapreza (La Jolla), an IV formulation of synthetic angiotensin II, to increase blood pressure in adults with septic or other vasodilatory shock, such as anaphylactic or neurogenic shock. Angiotensin is a naturally occurring peptide hormone in the renin-angiotensin-aldosterone system (RAAS). Giapreza is the first synthetic angiotensin II product to become available in the US.

TREATMENT OF SEPTIC SHOCK — Septic shock is the most common form of vasodilatory shock. It is characterized by reduced blood pressure and decreased organ perfusion, which can lead to irreversible organ damage.

Vasopressors are the standard treatment for septic shock when IV fluids alone do not raise blood pressure; recent guidelines recommend use of norepinephrine, a potent alpha1- and beta1-adrenergic agonist, as the initial vasopressor of choice. ... more      

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Title: Angiotensin II (Giapreza) for Septic Shock
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