The Medical Letter on Drugs and Therapeutics
FROM
ISSUE 1577
ISSUE 1577
July 29, 2019
Cyclosporine 0.09% Solution (Cequa) for Dry Eye Disease
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July 29, 2019 (Issue: 1577)
The FDA has approved cyclosporine 0.09% ophthalmic
solution (Cequa – Sun) to increase tear production
in patients with keratoconjunctivitis sicca (dry eye
disease). Restasis, a 0.05% cyclosporine emulsion,
was approved in the US in 2003 for the same indication.
... more
- EK Akpek et al. Dry Eye Syndrome Preferred Practice Pattern. Ophthalmology 2019; 126:P286.
- Drugs for some common eye disorders. Treat Guidel Med Lett 2012; 10:79.
- HD Perry et al. Evaluation of topical cyclosporine for the treatment of dry eye disease. Arch Ophthalmol 2008; 126:1046.
- Lifitegrast (Xiidra) for dry eye disease. Med Lett Drugs Ther 2016; 58:110.
- C Schultz. Safety and efficacy of cyclosporine in the treatment of chronic dry eye. Ophthamol Eye Dis 2014; 6:37.
- J Tauber et al. A phase II/III, randomized, double-masked, vehicle-controlled, dose-ranging study of the safety and efficacy of OTX-101 in the treatment of dry eye disease. Clin Ophthalmol 2018; 12:1921.
- DF Goldberg et al. A phase 3, randomized, double-masked study of OTX-101 ophthalmic solution 0.09% in the treatment of dry eye disease. Ophthalmology 2019 April 6 (epub).
- K Sall et al. Two multicenter, randomized studies of the efficacy and safety of cyclosporine ophthalmic emulsion in moderate to severe dry eye disease. CsA Phase 3 Study Group. Ophthalmology 2000; 107:631.

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