The Medical Letter on Drugs and Therapeutics
FROM
ISSUE 1587
ISSUE 1587
December 16, 2019
Darolutamide (Nubeqa) for Prostate Cancer
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December 16, 2019 (Issue: 1587)
The FDA has approved darolutamide (Nubeqa –
Bayer), an androgen receptor inhibitor, for oral
treatment of nonmetastatic castration-resistant
prostate cancer (nmCRPC). Darolutamide is the third
androgen receptor inhibitor to be approved for this
indication; apalutamide (Erleada) and enzalutamide
(Xtandi), which are also approved for use in patients
with metastatic castration-resistant prostate cancer
(mCRPC), were approved earlier.
... more
- Apalutamide (Erleada) for prostate cancer. Med Lett Drugs Ther 2018; 60:e124.
- Enzalutamide (Xtandi) for prostate cancer. Med Lett Drugs Ther 2013; 55:20.
- K Fizazi et al. Clinical development of darolutamide: a novel androgen receptor antagonist for the treatment of prostate cancer. Clin Genitourin Cancer 2018; 16:332.
- WT Lowrance et al. Castration-resistant prostate cancer: AUA Guideline amendment 2018. J Urol 2018; 200:1264.
- M Hussain et al. Enzalutamide in men with nonmetastatic, castration-resistant prostate cancer. N Engl J Med 2018; 378:2465.
- MR Smith et al. Apalutamide treatment and metastasis-free survival in prostate cancer. N Engl J Med 2018; 378:1408.
- K Fizazi et al. Darolutamide in nonmetastatic, castration-resistant prostate cancer. N Engl J Med 2019; 380:1235.
- Inhibitors and inducers of CYP enzymes and P-glycoprotein. Med Lett Drugs Ther 2019 September 20 (epub). Available at: medicalletter.org/downloads/CYP_PGP_Tables.pdf.

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