The Medical Letter on Drugs and Therapeutics
Elexacaftor/Tezacaftor/Ivacaftor (Trikafta) for Cystic Fibrosis
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The FDA has approved Trikafta (Vertex), a fixed-dose combination of the cystic fibrosis transmembrane conductance regulator (CFTR) modulators elexacaftor, tezacaftor, and ivacaftor, for oral treatment of cystic fibrosis (CF) in patients ≥12 years old who have at least one Phe508del mutation in the CFTR gene. About 90% of patients with CF have at least one copy of the Phe508del (also called F508del) mutation. This is the first approval for elexacaftor. Ivacaftor is available alone (Kalydeco) and in 2-drug combinations with tezacaftor (Symdeco) and lumacaftor (Orkambi). ... more
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Title: Elexacaftor Tezacaftor Ivacaftor (Trikafta) for Cystic Fibrosis
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