The Medical Letter on Drugs and Therapeutics
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ISSUE 1591
ISSUE 1591
February 10, 2020
Drospirenone (Slynd) - A New Progestin-Only Oral Contraceptive
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February 10, 2020 (Issue: 1591)
The FDA has approved a progestin-only oral
contraceptive ("minipill") containing drospirenone
(Slynd – Exeltis). All other progestin-only oral
contraceptives available in the US contain
norethindrone (Camila, and others). Progestin-only oral
contraceptives are similar in efficacy to combination
oral contraceptives. They are used predominantly by
breastfeeding women and by those in whom estrogen
is poorly tolerated or contraindicated. Combination
oral contraceptives containing drospirenone and
ethinyl estradiol have been available for years.
... more
- Choice of contraceptives. Med Lett Drugs Ther 2018; 60:161.
- J Trussell and ARA Aiken. Contraceptive efficacy. In: RA Hatcher et al. Contraceptive Technology: Twenty-first revised edition. New York, NY: Ayer Company Publishers 2018.
- IJM Duijkers et al. Maintenance of ovulation inhibition with a new progestogen-only pill containing drospirenone after scheduled 24-h delays in pill intake. Contraception 2016; 93:303.
- S Palacios et al. Multicenter, phase III trials on the contraceptive efficacy, tolerability and safety of a new drospirenone-only pill. Acta Obstet Gynecol Scand 2019; 98:1549.
- D Madigan and J Shin. Drospirenone-containing oral contraceptives and venous thromboembolism: an analysis of the FAERS database. Open Access J Contracept 2018; 9:29.
- Inhibitors and inducers of CYP enzymes and P-glycoprotein. Med Lett Drugs Ther 2019 November 6 (epub). Available at: medicalletter.org/downloads/CYP_PGP_Tables.pdf.

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Title: Drospirenone (Slynd) - A New Progestin-Only Oral Contraceptive
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