The Medical Letter on Drugs and Therapeutics
FROM
ISSUE 1605
ISSUE 1605
August 24, 2020
Phexxi - A Nonhormonal Contraceptive Gel
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August 24, 2020 (Issue: 1605)
The FDA has approved Phexxi (Evofem), a
nonhormonal prescription-only vaginal gel containing
lactic acid, citric acid, and potassium bitartrate, for
prevention of pregnancy. The gel is intended for on-demand
contraception; it is not effective when used
after intercourse. It was previously approved for
use as a vaginal lubricant (Amphora), but was never
marketed.
... more
- AL Nelson. An overview of properties of Amphora (Acidform) contraceptive vaginal gel. Expert Opin Drug Saf 2018; 17:935.
- Choice of contraceptives. Med Lett Drugs Ther 2018; 60:161.
- Committee on Practice Bulletins-Gynecology, Long-Acting Reversible Contraception Work Group. Practice bulletin No. 186: long-acting reversible contraception: implants and intrauterine devices. Obstet Gynecol 2017; 130:e251.
- J Zhou et al. The semen pH affects sperm motility and capacitation. PLoS ONE 2015; 10:e0132974.
- MA Thomas et al. A novel vaginal pH regulator: results from the phase 3 AMPOWER contraception clinical trial. Contracept X 2020; 2:100031.
- MA Thomas et al. Sexual satisfaction with the vaginal pH regulator: results from the AMPOWER clinical trial [32I]. Obstet Gynecol 2020; 135:100S.
- B Maximos et al. Genitourinary side effects with vaginal pH regulator: results from AMPOWER. [191]. Obstet Gynecol 2020; 135:96S.
- Approximate WAC. WAC = wholesaler acquisition cost or manufacturer's published price to wholesalers; WAC represents a published catalogue or list price and may not represent an actual transactional price. Source: AnalySource® Monthly. August 5, 2020. Reprinted with permission by First Databank, Inc. All rights reserved. ©2020. www.fdbhealth.com/drug-pricing-policy.

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Title: Phexxi - A Nonhormonal Contraceptive Gel
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