IV Amisulpride (Barhemsys) for Postoperative Nausea and Vomiting
IV Amisulpride (Barhemsys) for Postoperative Nausea and Vomiting
December 28, 2020 (Issue: 1614)
The FDA has approved IV amisulpride (Barhemsys –
Acacia), a selective dopamine-2 and -3 (D2/D3) receptor
antagonist, for prevention and treatment of postoperative
nausea and vomiting (PONV) in adults. It is the first
antiemetic to be approved...more
- TJ Gan et al. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 2014; 118:85.
- E Obrink et al. Post-operative nausea and vomiting: update on predicting the probability and ways to minimize its occurrence, with focus on ambulatory surgery. Int J Surg. 2015; 15:100.
- TJ Gan et al. Intravenous amisulpride for the prevention of postoperative nausea and vomiting: two concurrent, randomized, double-blind, placebo-controlled trials. Anesthesiology 2017; 126:268.
- P Kranke et al. Amisulpride prevents postoperative nausea and vomiting in patients at high risk: a randomized, double blind, placebo-controlled trial. Anesthesiology 2018; 128:1099.
- KA Candiotti et al. Randomized, double-blind, placebocontrolled study of intravenous amisulpride as treatment of established postoperative nausea and vomiting in patients who have had no prior prophylaxis. Anesth Analg 2019; 128:1098.
- AS Habib et al. Amisulpride for the rescue treatment of postoperative nausea or vomiting in patients failing prophylaxis: a randomized, placebo-controlled phase III trial. Anesthesiology 2019; 130:203.
- GM Fox et al. Intravenous amisulpride does not meaningfully prolong the QTc interval at doses effective for the management of postoperative nausea and vomiting. Anesth Analg 2019 Dec 9 (epub).
- RL Woosley et al. QT drugs list. Available at www.crediblemeds.org. Accessed December 10, 2020.
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