The Medical Letter on Drugs and Therapeutics
Cabotegravir/Rilpivirine (Cabenuva) for HIV-1 Infection
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The FDA has approved Cabenuva (ViiV Healthcare), an extended-release formulation of the new integrase strand transfer inhibitor (INSTI) cabotegravir copackaged with an extended-release formulation of the non-nucleoside reverse transcriptase inhibitor (NNRTI) rilpivirine, as a once-monthly complete regimen for intramuscular (IM) treatment of adults with HIV-1 infection who are virologically suppressed (HIV-1 RNA <50 copies/mL) on a stable antiretroviral (ARV) regimen, have no history of treatment failure, and have no known or suspected resistance to either drug. Oral cabotegravir (Vocabria) was also approved by the FDA for use in combination with oral rilpivirine (Edurant) as a daily one-month lead-in regimen before starting treatment with the monthly IM combination. Cabenuva is the first complete long-acting regimen to be approved by the FDA for treatment of HIV-1 infection. ... more
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Title: Cabotegravir Rilpivirine (Cabenuva) for HIV-1 Infection
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