The Medical Letter on Drugs and Therapeutics
Olanzapine/Samidorphan (Lybalvi) for Schizophrenia and Bipolar Disorder
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The FDA has approved Lybalvi (Alkermes), a fixed-dose combination of the second-generation antipsychotic olanzapine (Zyprexa, and generics) and samidorphan, a new opioid antagonist, for treatment of adults with schizophrenia or with manic or mixed episodes of bipolar I disorder. The addition of samidorphan is intended to mitigate the weight gain that occurs with olanzapine. This is the first FDA approval for samidorphan. ... more
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Title: Olanzapine Samidorphan (Lybalvi) for Schizophrenia and Bipolar Disorder
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