Treatment Guidelines from The Medical Letter
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ISSUE
86
Drugs for Tuberculosis
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Even though the incidence continues to decline in the United States,1 tuberculosis (TB) is still a common cause of death worldwide, and the prevalence of drug-resistant TB poses severe challenges to its treatment and control.2,3 Guidelines with detailed management recommendations are available from the Centers for Disease Control and Prevention (CDC), American Thoracic Society and Infectious Diseases Society of America (IDSA).4

DIRECTLY OBSERVED THERAPY

Poor adherence to TB therapy is the most common cause of treatment failure and can lead to drug resistance. Medical Letter consultants recommend that most patients, including those with disease due to drug-susceptible strains, take drugs for active TB under direct observation. Compared to self-administered regimens, directly observed therapy (DOT) has been shown to decrease drug resistance, relapse rates ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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Title: Drugs for Tuberculosis
Article code: 86a
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