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Eslicarbazepine Acetate (Aptiom) for Epilepsy
The Medical Letter on Drugs and Therapeutics • May 26, 2014 (Issue 1443)
, such as clobazam and omeprazole,
and decrease serum concentrations of drugs
metabolized by CYP3A4 ...
Eslicarbazepine acetate (Aptiom – Sunovion) has been
approved by the FDA for adjunctive treatment of partial-onset
seizures in adults. New drugs for epilepsy are
often approved by the FDA initially only as adjunctive
treatment for partial seizures. Eslicarbazepine acetate
is a prodrug of eslicarbazepine, which is the S-isomer of
the active metabolite of oxcarbazepine. Oxcarbazepine
itself is similar to carbamazepine. Both oxcarbazepine
and carbamazepine are available generically.