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In Brief: Trijardy XR - A New 3-Drug Combination for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • Jun 01, 2020  (Issue 1599)
mg ER tabs3 Linagliptin/metformin ER2 – Jentadueto XR 2.5/1000, 5/1000 mg ER tabs3 5/1000-5/2000 mg ...
The FDA has approved Trijardy XR (Boehringer Ingelheim/Lilly), a fixed-dose combination of the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin, the dipeptidyl peptidase-4 (DPP-4) inhibitor linagliptin, and extended-release metformin, for oral treatment of type 2 diabetes in adults. Empagliflozin and linagliptin have been available in a fixed-dose combination as Glyxambi since 2015, and both have been available in 2-drug combinations with extended-release metformin for years (see Table 1).
Med Lett Drugs Ther. 2020 Jun 1;62(1599):88 |  Show IntroductionHide Introduction

Drugs for Type 2 Diabetes

   
The Medical Letter on Drugs and Therapeutics • Nov 14, 2022  (Issue 1663)
Jentadueto 500/2.5, 850/2.5, 1000/2.5 mg tabs 500/2.5-1000/2.5 mg PO bid4 436.20 (Boehringer Ingelheim ...
Diet, exercise, and weight loss can improve glycemic control, but almost all patients with type 2 diabetes require antihyperglycemic drug therapy. Treating to a target A1C of <7% while minimizing hypoglycemia is recommended to prevent microvascular complications of diabetes (retinopathy, nephropathy, and neuropathy). An A1C target of <8% may be appropriate for some older patients.
Med Lett Drugs Ther. 2022 Nov 14;64(1663):177-84 |  Show IntroductionHide Introduction