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See also: modafinil

Xywav - A Mixed-Salt Oxybate Oral Solution for Idiopathic Hypersomnia

   
The Medical Letter on Drugs and Therapeutics • Dec 27, 2021  (Issue 1640)
such as modafinil (Provigil, and generics), armodafinil (Nuvigil, and generics), and methylphenidate (Ritalin ...
Xywav (Jazz), an oral solution that contains calcium, magnesium, potassium, and sodium oxybates, has been approved by the FDA for treatment of idiopathic hypersomnia in adults. It is the first drug to be approved in the US for this indication. Xywav was approved in 2020 for treatment of excessive daytime sleepiness or cataplexy in patients ≥7 years old with narcolepsy. It contains about 92% less sodium than sodium oxybate oral solution (Xyrem), which has been available in the US for years for use in patients ≥7 years old with narcolepsy.
Med Lett Drugs Ther. 2021 Dec 27;63(1640):207-8 |  Show IntroductionHide Introduction

Pitolisant (Wakix) for Narcolepsy

   
The Medical Letter on Drugs and Therapeutics • Feb 08, 2021  (Issue 1617)
modafinil (Provigil, and generics) and its R-enantiomer armodafinil (Nuvigil, and generics) have been used ...
The FDA has approved pitolisant (Wakix – Harmony), a histamine-3 (H3)-receptor antagonist/inverse agonist, for treatment of excessive daytime sleepiness (EDS) or cataplexy in adults with narcolepsy. It is the first H3-receptor antagonist/inverse agonist to become available in the US and the first non-controlled substance to receive FDA approval for these indications. Pitolisant has been available in Europe since 2016.
Med Lett Drugs Ther. 2021 Feb 8;63(1617):19-21 |  Show IntroductionHide Introduction