A new once-daily, low-dose oral formulation of doxycycline monohydrate (Oracea - CollaGenex) has been approved by the FDA for treatment of inflammatory papules and pustules associated with rosacea in adults.

Dasatinib (Sprycel - Bristol-Myers Squibb), an inhibitor of multiple tyrosine kinases, has been approved by the FDA for second-line treatment of chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) in adults.

Medical Letter consultants have brought to our attention some confusion that has accompanied the release of Adacel, a combination of tetanus toxoid, diphtheria toxoid and acellular pertussis antigens (Tdap) recently approved for use as a booster in adolescents and adults 11-64 years old (Med Lett Drugs Ther 2006; 48:5). Another Tdap vaccine, Boostrix, is approved for use in adolescents 10-18 years old. Some adults have inadvertently been immunized with Daptacel or Infanrix (DTaP), which are intended for active immunization of infants and children 6 weeks to 6 years old. Such mix-ups were reported by the Institute for Safe Medication Practices (www.ismp.org) in the August 24 and December 2006 issues of its newsletter.

The problem with giving these pediatric vaccines to adults is that they contain more diphtheria and pertussis antigens than the adult vaccine, and adults may have untoward reactions to these higher antigen levels. One consultant who inadvertently gave the pediatric vaccine to 80 adults reports that a few developed fever to 102ºF, and several developed severe erythema and swelling at the injection site. In the absence of a comparative trial, whether these reactions were due to the higher antigen load can only be a matter of speculation.

The reasons for the mix-ups, according to the Institute, include the similarities in the brand names and packaging of Adacel and Daptacel in addition to the similar component antigens in the 2 products (the components of Adacel are listed in a different order and are labeled as “reduced” diphtheria toxoid and acellular pertussis). The manufacturer of Adacel and Daptacel intends to make changes in the packaging and labeling to clarify the differences between the products. The inadvertent administration of Infanrix to adults was caused by an electronic order entry program’s failure to differentiate between the adult and pediatric vaccines.

Download U.S. English