Treatment Guidelines from The Medical Letter
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Antithrombotic Drugs
Updated March 2012

Arterial thrombi are composed mainly of platelet aggregates held together by small amounts of fibrin. Antiplatelet drugs are the drugs of choice for prevention and treatment of arterial thrombosis, but anticoagulants are also effective, and their effects can add to those of antiplatelet drugs. Venous thrombi are composed mainly of fibrin and trapped red blood cells, with relatively few platelets. Anticoagulants are the agents of choice for prevention and treatment of venous thromboembolism and for prevention of cardioembolic events in patients with atrial fibrillation.


Antiplatelet drugs are used mainly for primary and secondary prevention and treatment of acute coronary syndrome (ACS), which includes unstable angina/non- ST-elevation myocardial infarction (UA/NSTEMI), ST-elevation myocardial infarction (STEMI) and percutaneous coronary intervention (PCI).

ASPIRIN — ... more      

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