The Medical Letter on Drugs and Therapeutics
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1298
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Prostate Cancer Screening

The US Preventive Services Task Force (USPSTF) has recently concluded that available evidence is insufficient to assess the balance between potential benefits and harms of using the prostate-specific antigen (PSA) to screen men <75 years old for prostate cancer and has recommended against screening men >75 years old.1 The median age of death from prostate cancer is 80.

Other professional organizations including the American Urological Association,2 the American Cancer Society,3 and the National Comprehensive Cancer Network (NCCN)4 recommend offering annual PSA screening to men >50 years old for those at average risk, and to younger men who are African-American or have risk factors such as a family history of the disease. The NCCN recommends obtaining a baseline PSA at age 40, beginning annual screening at age 50 and considering a prostate biopsy ... more      

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