The Medical Letter on Drugs and Therapeutics
Deep Brain Stimulation for Parkinson's Disease
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Deep brain stimulation (DBS) is increasingly used to treat advanced Parkinson's disease (PD), but few controlled clinical trials have been published. New evidence from a large controlled study has recently become available.

SURGICAL TREATMENT OF PARKINSON’S DISEASE — Medical therapy is effective for initial treatment of Parkinson's disease.1 Surgery should generally be reserved for patients with tremor that is refractory to medical treatment or for those with major dyskinesias or clinical fluctuations while on levodopa (Sinemet, and others). Surgery does not help patients who were unresponsive to levodopa. Appropriate candidates for surgery are those whose cognition is relatively intact on full neuropsychological testing.

DBS — Bilateral DBS of the subthalamic nucleus with continuous high-frequency electrical stimuli from electrodes implanted in the brain (connected ... more      

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Title: Deep Brain Stimulation for Parkinson's Disease
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