The Medical Letter on Drugs and Therapeutics
Dalfampridine (Ampyra) for MS
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The FDA has approved the use of dalfampridine (4-aminopyridine; Ampyra – Acorda), a potassium channel blocker, to improve walking speed in patients with multiple sclerosis (MS). Walking speed is considered a reliable clinical measure of impairment in patients with MS.

DRUGS FOR MS — Current treatments for relapsing forms of MS include interferon beta, glatiramer acetate (Copaxone), mitoxantrone (Novantrone) and natalizumab (Tysabri).1 Rituximab (Rituxan) and alemtuzumab (Campath) have also been used off-label for this indication.2 Formulations of 4-aminopyridine prepared by compounding pharmacies have been used in clinical practice in MS patients for several years; anecodotal reports have suggested that they improve motor function and decrease fatigue.

MECHANISM OF ACTION — The exact mechanism ... more      

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Title: Dalfampridine (Ampyra) for MS
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