ISSUE 1361
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The FDA has approved an intravenous (IV) formulation of acetaminophen (Ofirmev – Cadence) for use in patients ≥2 years old for management of pain either as monotherapy (mild to moderate pain) or with an opioid (moderate to severe pain) and for reduction of fever.
FORMULATIONS — An IV formulation of propacetamol, a prodrug of acetaminophen, has been available in Europe for more than 20 years, but needs reconstitution and has been associated with pain on injection. An IV formulation of acetaminophen itself that does not require reconstitution and is less likely to cause pain on injection has been available in Europe since 2002.
IV NONOPIOIDS FOR PAIN — Ketorolac was the first nonsteroidal anti-inflammatory drug (NSAID) to become available in an injectable formulation in the US; it is marketed for short-term (up to 5 days) use. IV or intramuscular ketorolac is comparable
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3. ST Duggan and LJ Scott. Intravenous paracetamol (acetaminophen). Drugs 2009; 69:101.
8. Pharmaceutical drug overdose. Treat Guidel Med Lett 2006; 4:61.
9. Addendum: warfarin-acetaminophen interaction. Med Lett Drugs Ther 2008; 50:45.
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