The Medical Letter on Drugs and Therapeutics
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1376
A Fixed-Dose Combination of Ibuprofen and Famotidine (Duexis)
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Revised 11/9/11: In the clinical studies section, the overall incidence of endoscopic gastroduodenal ulcers should have been 11% with Duexis and 21.9% with ibuprofen alone and, in low dose aspirin users, 12.8% with Duexis and 32.8% with ibuprofen alone.

The FDA has approved Duexis (Horizon), a fixed-dose combination of the nonsteroidal anti-inflammatory drug (NSAID) ibuprofen and the H2-receptor antagonist (H2RA) famotidine, for symptomatic relief of osteoarthritis and rheumatoid arthritis and to decrease the risk of developing gastric and duodenal ulcers in patients at risk for NSAID-associated ulcers. Vimovo, a combination of the NSAID naproxen and the proton pump inhibitor (PPI) esomeprazole, is also approved by the FDA for prevention of NSAID-associated gastric ulcers.1

NSAIDs AND GI TOXICITY — NSAIDs inhibit synthesis of prostaglandins, which have a protective effect on the gastric mucosa. They are more likely to cause gastric than duodenal ulcers.2 Up to 40% of chronic NSAID users report having dyspepsia, and 1-2% develop life-threatening consequences of peptic ulcer ... more       Show References Hide References

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Title: A Fixed-Dose Combination of Ibuprofen and Famotidine (Duexis)
Article code: 1376a
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