The Medical Letter on Drugs and Therapeutics
Safety of Dronedarone (Multaq)
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Dronedarone (Multaq – Sanofi), an analog of amiodarone, was approved by the FDA in 2009 for oral treatment of paroxysmal or persistent (non-permanent) atrial fibrillation or atrial flutter.1 Amiodarone (Cordarone, and others) is more effective for this indication,2 but its use is often limited by its adverse effects, including thyroid and pulmonary toxicity.

ADVERSE EFFECTS OF DRONEDARONE — Diarrhea, nausea, vomiting, abdominal pain and rash can occur with dronedarone, but unlike amiodarone, significant thyroid or ocular toxicity has not been reported to date. Photosensitivity has been reported, but not the blue-gray skin discoloration associated with amiodarone. Both amiodarone and dronedarone have the potential to interact with many other drugs taken concomitantly.

After an earlier trial was terminated prematurely ... more      

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Title: Safety of Dronedarone (Multaq)
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