The Medical Letter on Drugs and Therapeutics
TNF Inhibitors for Crohn's Disease: When, Which, and for How Long
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Three tumor necrosis factor (TNF) inhibitors – infliximab (Remicade), adalimumab (Humira), and certolizumab pegol (Cimzia) – are approved by the FDA for treatment of moderately to severely active Crohn's disease in adults who have had an inadequate response to conventional therapy. Infliximab is also FDA-approved for the same indication in children ≥6 years old and for treatment of fistulas in adults. All 3 TNF inhibitors have been shown to reduce the signs and symptoms of Crohn's disease in clinical trials.1,2 They have been associated with adverse effects such as tuberculosis, other serious infections, and lymphoma, and they are expensive.1

CLINICAL USE — In addition to being used for treatment of disease that has not responded to other drugs, TNF inhibitors have been effectively used (off-label) as ... more      

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Title: TNF Inhibitors for Crohn's Disease: When, Which, and for How Long
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