The Medical Letter on Drugs and Therapeutics
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1444
Extended-Release Hydrocodone (Zohydro ER) for Pain
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The FDA has approved an extended-release oral formulation of the opioid agonist hydrocodone (Zohydro ER – Zogenix) for management of pain severe enough to require continuous, long-term therapy and for which alternative treatment options are inadequate. Zohydro ER is the first single-ingredient hydrocodone product to be marketed in the US. Hydrocodone has been available for years in combination with acetaminophen (Vicodin, and others) or ibuprofen (Vicoprofen, and others).1

PHARMACOLOGY — Hydrocodone is a semisynthetic opioid. It is metabolized primarily by CYP3A4-mediated N-demethylation to norhydrocodone and to a lesser extent by CYP2D6-mediated O-demethylation to hydromorphone. Overall hydrocodone exposure is similar after administration of Zohydro ER or comparable daily doses of immediate-release hydrocodone combination products, but ... more      

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Title: Extended-Release Hydrocodone (Zohydro ER) for Pain
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