The Medical Letter on Drugs and Therapeutics
Sublingual Immunotherapy for Allergic Rhinitis
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The FDA has approved 3 allergen extracts for sublingual administration as immunotherapy for allergic rhinitis confirmed by a positive skin test or in vitro testing for pollen-specific IgE antibodies: Oralair (Stallergenes S.A./Greer) and Grastek (Merck) for grass pollen-induced allergic rhinitis and Ragwitek (Merck) for short ragweed pollen-induced allergic rhinitis.

ALLERGIC RHINITIS — Orally administered second-generation H1-antihistamines are the preferred first-line therapy for relief of itching, sneezing, and rhinorrhea associated with mild to moderate allergic rhinitis. Intranasal corticosteroids are the most effective drugs available for prevention and relief of allergic rhinitis symptoms, including itching, sneezing, discharge, and congestion, and are the drugs of choice for moderate to severe disease. ... more      

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Title: Sublingual Immunotherapy for Allergic Rhinitis
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