The Medical Letter on Drugs and Therapeutics
FROM
ISSUE 1452
ISSUE 1452
September 29, 2014
Drugs for Postmenopausal Osteoporosis
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September 29, 2014 (Issue: 1452)
Superseded by The Medical Letter "Drugs for Postmenopausal Osteoporosis" - Issue 1602, July 13, 2020
US guidelines for the treatment of osteoporosis have
been published. The diagnosis of osteoporosis has
traditionally been established by the occurrence of
fragility fractures or by bone densitometry, which is
generally reported in terms of standard deviations (SD)
from mean values in young adults (T-score). The World
Health Organization (WHO) has defined normal bone
mineral density (BMD) for women as a value within one
SD of the young adult mean. Values 2.5 SD or more
below the mean (T-score -2.5 or below) at the spine,
femoral neck, or total hip are defined as osteoporosis.
The WHO has developed a computerized model (FRAX)
that predicts the 10-year probability of a hip fracture or
other major osteoporotic fracture based on clinical risk
factors and BMD at the
... more
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