The Medical Letter on Drugs and Therapeutics
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1453
Empagliflozin (Jardiance) for Diabetes
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Empagliflozin (Jardiance – Boehringer Ingelheim/Lilly), an SGLT2 inhibitor, has been approved by the FDA for oral treatment of type 2 diabetes. It is the third SGLT2 inhibitor to be approved for this indication.1,2

MECHANISM OF ACTION — SGLT2 (sodium-glucose co-transporter 2), a membrane protein expressed mainly in the kidney, transports filtered glucose from the proximal renal tubule into tubular epithelial cells. SGLT2 inhibitors decrease renal glucose reabsorption and increase urinary glucose excretion, resulting in a reduction in blood glucose levels.

CLINICAL STUDIES — In randomized, double-blind trials in patients with type 2 diabetes, use of empagliflozin, alone and in combination with metformin, a sulfonylurea, pioglitazone, or insulin, reduced HbA1c significantly more than placebo. Treatment with empagliflozin also resulted in ... more      

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Title: Empagliflozin (Jardiance) for Diabetes
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