The Medical Letter on Drugs and Therapeutics
Rescheduling of Hydrocodone Combination Products
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The Drug Enforcement Administration (DEA) has reclassified all hydrocodone combination products as schedule II controlled substances; they were previously classified as schedule III.1 Hydrocodone alone (Zohydro ER) is already a schedule II controlled substance.2

HYDROCODONE — Hydrocodone is a semisynthetic opioid agonist. It is widely prescribed in combination with acetaminophen or ibuprofen for treatment of pain3 and is also available in combination with homatropine, chlorpheniramine, and/or pseudoephedrine for relief of cough and nasal congestion.

THE NEW SCHEDULE — Schedule II controlled substances are those that have an accepted medical use in the US and a high potential for abuse that can result in severe psychological and physical dependence. Drugs classified ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

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Title: Rescheduling of Hydrocodone Combination Products
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