The Medical Letter on Drugs and Therapeutics
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Two New GLP-1 Receptor Agonists for Diabetes

Two new injectable GLP-1 (glucagon-like peptide-1) receptor agonists, dulaglutide (Trulicity [trū li si tee] – Lilly) and albiglutide (Tanzeum [tan' zee um] – GSK), have been approved by the FDA for once-weekly treatment of type 2 diabetes. Other available GLP-1 receptor agonists include exenatide, which is approved for injection twice daily (Byetta) or once weekly (Bydureon), and liraglutide (Victoza), which is injected once daily.

GLP-1 RECEPTOR AGONISTS — When metformin alone fails to control hyperglycemia, addition of a GLP-1 receptor agonist is an option. These drugs are less likely than sulfonylureas or insulin to cause hypoglycemia and usually cause weight loss, but they are expensive and long-term safety data are lacking.1

Mechanism of Action – Released by cells in the gastrointestinal tract in response ... more      

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