The Medical Letter on Drugs and Therapeutics
Pembrolizumab (Keytruda) for Metastatic Melanoma (online only)
The full article is available to subscribers Subscriber Login   

The FDA has approved pembrolizumab (Keytruda – Merck), a human programmed death receptor-1 (PD-1) blocking antibody, for treatment of unresectable or metastatic melanoma that has progressed following treatment with ipilimumab (Yervoy) and, if the patient is BRAF V600 mutation positive, a BRAF inhibitor. It is the first PD-1 inhibitor to be marketed in the US. Nivolumab, another PD-1 inhibitor, is available in Japan. Pembrolizumab was previously known as lambrolizumab.

STANDARD TREATMENT — Metastatic melanoma has traditionally been treated with the cytotoxic agent dacarbazine (DTIC), which has not been shown to improve survival. Other therapies have included high-dose interleukin-2 (aldesleukin, Proleukin), which has produced responses in 16% of patients, but can cause severe toxicity and requires hospitalization for treatment. The anti-CTLA4 monoclonal antibody ipilimumab has produced response ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Immediate Online access to current issue and archives from 1988 to the present
  • Mobile access to our mobile site and free apps for iOS, Android and Kindle
  • FREE online per issue CME/CE
Free trial offer
3 Free Issues of The Medical Letter on Drugs and Therapeutics mailed to your home or office PLUS online access.
Try a Free Trial Subscription
Purchase this article:
Title: Pembrolizumab (Keytruda) for Metastatic Melanoma (online only)
Article code: 1455e
 Electronic, downloadable article - $25