The Medical Letter on Drugs and Therapeutics
FROM
ISSUE
1457
Secondary Prevention of Stroke
The full article is available to subscribers Subscriber Login   
Revised 2/23/15: In the Clopidogrel Plus Aspirin section, the last sentence has been revised. In the Conclusion, "90 days" has been changed to "21 days".

Recent guidelines from the American Heart Association and American Stroke Association reviewed antithrombotic therapy options for secondary prevention of stroke in patients who have had a stroke or transient ischemic attack (TIA).1

ASPIRIN — Aspirin monotherapy has been shown to reduce the risk of secondary stroke by about 15%. In doses ≤325 mg/day, the annual risk of serious gastrointestinal hemorrhage is about 0.4%, which is 2.5 times the risk without aspirin.2

DIPYRIDAMOLE PLUS ASPIRIN — The antiplatelet drug dipyridamole (Persantine, and generics) is available in combination with aspirin (Aggrenox, and generics). A randomized, controlled trial (ESPRIT) in 2739 patients who had a TIA or minor stroke in the previous 6 months found that a combination of extended-release dipyridamole (200 mg bid) ... more      

The Medical Letter is a subscriber-funded nonprofit organization that publishes critical appraisals of new prescription drugs and comparative reviews of drugs for common diseases.

Would you like to read the rest of this article?  Gain access below.

Subscribe
Subscriptions to The Medical Letter on Drugs and Therapeutics include:
  • Print version published and mailed biweekly (26 issues/year)
  • Unlimited online access to current and past issues (1988 - present)
  • Mobile App for iOS, Android, and Kindle Fire
  • FREE online per issue CME/CE
Purchase this article:
Title: Secondary Prevention of Stroke
Article code: 1457d
 Electronic, downloadable article - $45
Gain access through your organization
Ask your librarian to consider an Institutional Subscription to The Medical Letter.
Recommend to your librarian