The Medical Letter on Drugs and Therapeutics
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Carbidopa/Levodopa Extended-Release Capsules (Rytary)

The FDA has approved a new formulation of carbidopa/levodopa (Rytary – Impax) in extended-release capsules for treatment of Parkinson's disease (PD).

CARBIDOPA/LEVODOPA — The combination of levodopa and carbidopa is still the most effective pharmacologic treatment for symptomatic relief of PD.1 It has been available for many years as immediate- and sustained-release tablets (Sinemet, Sinemet CR, and generics), orally disintegrating tablets, and in combination with the COMT inhibitor entacapone (Stalevo, and generics). Sustained-release tablets have a slower and less predictable onset of action than immediate-release tablets. Many patients must take a half or a whole immediate-release tablet concomitantly with sustained-release tablets, particularly with the first dose of the day. Some small studies in patients with PD fluctuations have found ... more      

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