The Medical Letter on Drugs and Therapeutics
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Drugs for Psoriasis

Mild to moderate psoriasis is generally treated with topical corticosteroids. Vitamin D analogs and tazarotene are topical alternatives that can be used in combination with topical corticosteroids. Phototherapy and systemic therapy, including biologic agents, are recommended for patients with moderate to severe disease.

Drugs for psoriatic arthritis are reviewed in a separate article available at

TOPICAL THERAPY — Corticosteroids – Topical corticosteroids are widely used for treatment of psoriasis both alone and in combination with phototherapy and systemic therapy. Ointments are generally the most effective. Foams and sprays can be applied to large areas, but the alcohol base used in many of them may cause burning in patients with sensitive skin.

Adverse Effects – Superpotent topical corticosteroids, such ... more      

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