The Medical Letter on Drugs and Therapeutics
Budesonide Rectal Foam (Uceris) for Ulcerative Colitis
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The FDA has approved a rectal foam formulation of the corticosteroid budesonide (Uceris - Salix/Valeant) for induction of remission in patients with active mild to moderate distal ulcerative colitis (UC) extending up to 40 cm from the anal verge. Budesonide is also available as oral extended-release tablets (also branded as Uceris) for use in patients with UC and as oral enteric-coated tablets (Entocort EC, and generics) for treatment of Crohn's disease.1,2

TOPICAL TREATMENT OF DISTAL UC – Rectally instilled aminosalicylates and corticosteroids can induce remission in mild to moderate distal UC. Enemas reach the splenic flexure, but may be difficult for patients to tolerate. Hydrocortisone rectal foam (Cortifoam) and mesalamine rectal suppositories (Canasa) are better tolerated, but their activity is generally limited to the 15 cm and ... more      

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Title: Budesonide Rectal Foam (Uceris) for Ulcerative Colitis
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